TRIAMCINOLONE DIACETATE

PRODUCT IDENTIFICATION

CAS NO. 124-94-7 (Base), 67-78-7  (Diacetate)

TRIAMCINOLONE DIACETATE

EINECS NO. 200-669-0
FORMULA C25H31FO8
MOL WT. 478.51

H.S. CODE

 

TOXICITY

 
SYNONYMS Triamcinolone 16alpha,21-diacetate
16a,21-Diacetoxy-9a-fluoro-11b,17a-dihydroxy-1,4-pregnadiene-3,20-dione 9a-Fluoro-16a-hydroxyprednisolone 16,21-diacetate
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT  
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

 

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS

Triamcinolone is a synthetic steroid of the glucocorticoid family. It is a mimic of natural cortisol (hydrocortisone), acorticosteroid hormone produced by the adrenal cortex. Triamcinolone has a fluorine atom in stead of hydrogen at 9 position. It is used clinically as an anti-inflammatory and immunomodulator in a wide variety of conditions, including rashes, hemorrhoids, arthritis, and inflammatory bowel disease. It is used in the replacement therapy for adrenal insufficiency. Commercially available esters of triamcinolone include:
  • Triamcinolone Benetonide [CAS #: 31002-79-6]
  • Triamcinolone Furetonide [CAS #: 4989-94-0]
  • Triamcinolone Hexacetonide [CAS #: 5611-51-8]
  • Triamcinolone Diacetate [CAS #: 67-78-7]
  • Triamcinolone Acetonide [CAS #: 76-25-5]
SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

IDENTIFICATION 

Infrared absorption (conforms to USP)
Ultraviolet absorption (conforms to USP)

ASSAY

97.0 - 102.0% (Anhydrous Basis)

WATER

6.0% max

HEAVY METALS

20ppm max

RESIDUE ON IGNITION

0.5% max

SPECIFIC ROTATION

+39° ~ +45°

TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 40, Safety Phrases: 36/37-45

GENERAL DESCRIPTION OF CORTICOSTEROID

Corticosteroid is a synthetic or naturally occurring 21-carbon steroid structure substances with four fused rings and vary functional branches attached to the ring system. Cholesterol and steroid hormones have this carbon skeleton. The term steroid refers to these three groups that contain a hydrogenated cyclopentano perhydro phenanthrene ring system. In restricted context for medical usage by non-endocrinologists, it refers to corticosteroids. Natural corticosteroids are elaborated by the adrenal cortex in response to physiological carbohydrate metabolism. According to their predominant biologic activity, they are divided into two major groups: glucocorticoid and mineralocorticoid. Glucocorticoid's chief function is to regulate carbohydrate, lipid, and protein metabolism and inhibit the release of ACTH (adrenocorticotropic hormone). Glucocorticoids also affect muscle tone and the microcirculation, participate in the maintenance of arterial blood pressure, increase gastric secretion, alter connective tissue response to injury, impede cartilage production, inhibit inflammatory, allergic, and immunologic responses, invoke shrinkage of lymphatic tissue, reduce the number of circulating lymphocytes, and affect the functions of the central nervous system. In humans, the most important ones are cortisol, cortisone, and corticosterone. Mineralocorticoids, uniuqely aldosterone in human, regulate the balance of water and promote retention of sodium, loss of potassium. Aldosterone plays a role also in promoting tissue repair. Spironolactone is the aldosterone antagonist called potassium-sparing diuretic used in the treatment of hypertension. Corticosteroids are used in clinically for hormonal replacement therapy, for suppression of ACTH, as antineoplastic, antiallergic, and anti-inflammatory agents, and to suppress immune responses.
  • Glucocorticoid Receptor Agonists
    • Dexamethasone
    • Triamcinolone
    • Hydrocortisone
    • Prednisone
  • Glucocorticoid Receptor Antagonists
    • Mifepristone
    • Onapristone
  • Mineralocorticoid Receptor Agonists
    • Aldosterone
  • Mineralocorticoid Receptor Antagonists
    • Spironolactone
    • Eplerenone